Several studies in adolescents demonstrate the effectiveness of risperidone for treating disruptive and aggressive behaviors. Risperidone is a widely prescribed atypical antipsychotic agent that seems to be effective in behavioral problems, including hyperactivity, irritability, aggressiveness, self-injurious behavior, and stereotypies. Risperidone, a benzisoxazole derivative, is a novel antipsychotic agent that combines potent serotonin (5-hydroxytryptamine, 5-HT2) and dopamine (D2) receptor antagonism. The reappearance of edema on rechallenge is strong evidence implicating risperidone as the cause of the swelling. Risperidone was then administered again, and the swelling returned so that the patient had to discontinue taking the drug. Risperidone was discontinued for a week, and the swelling resolved completely. The results of liver and renal function tests and rheumatologic tests were found to be within normal limits. After 20 days, she returned and reported partial improvement in her symptoms, although she had developed severe swelling of the hands and feet. She was diagnosed with major depression with psychotic signs and began treatment with risperidone (2 mg/night) and citalopram (20 mg/day). An 80-year-old female presented with symptoms of depression, worthlessness, hopelessness, loss of energy, insomnia, impatience, and forgetfulness associated with persecutory delusion that had begun about one year before her visit.